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Methylation is a fundamental biochemical process — adding a methyl group (CH3) to DNA, proteins, and neurotransmitters — that influences gene expression, detoxification, mood, and cardiovascular health.
Fasting activates autophagy — your body's cellular cleanup system that removes damaged proteins and organelles
High-dose antioxidant supplements (vitamin E, beta-carotene) have failed to extend lifespan and may increase mortality in some populations
Telomere length reflects biological vs chronological age — shorter telomeres predict cardiovascular disease, diabetes, cancer, and mortality
Fasting insulin is the earliest marker of metabolic dysfunction — it rises years before glucose, A1C, or cholesterol become abnormal
NAD+ levels decline approximately 50% between ages 40-60, impairing mitochondrial function, DNA repair, and sirtuin activity