Intermittent Fasting for Longevity: Evidence and Protocols
Fasting activates autophagy — your body's cellular cleanup system that removes damaged proteins and organelles
10 min readApr 26, 2026
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Fasting activates autophagy — your body's cellular cleanup system that removes damaged proteins and organelles
High-dose antioxidant supplements (vitamin E, beta-carotene) have failed to extend lifespan and may increase mortality in some populations
Telomere length reflects biological vs chronological age — shorter telomeres predict cardiovascular disease, diabetes, cancer, and mortality
Fasting insulin is the earliest marker of metabolic dysfunction — it rises years before glucose, A1C, or cholesterol become abnormal
NAD+ levels decline approximately 50% between ages 40-60, impairing mitochondrial function, DNA repair, and sirtuin activity