Discover
About
For Practitioners
ME/CFS involves documented mitochondrial dysfunction — this is the biological rationale for mitochondrial support supplements, not generic 'energy boosting'
ME/CFS is a multi-system illness with documented biological mechanisms including mitochondrial dysfunction, immune dysregulation, and autonomic nervous system disruption
ME/CFS diagnosis is clinical — based on meeting IOM 2015 criteria and ruling out other conditions that could explain symptoms
Fatigue is a symptom with multiple root causes — thyroid dysfunction, iron deficiency, blood sugar imbalance, HPA axis dysregulation, gut issues, and mitochondrial dysfunction are among the most common
CoQ10/ubiquinol is the most well-researched mitochondrial supplement, essential for electron transport chain function and especially critical for statin users.
Mitochondria produce ~70 kg of ATP daily; when they falter, cellular energy drops and you feel bone-deep fatigue
Adrenal fatigue isn't a recognized diagnosis, but HPA axis dysfunction is real and testable — your brain's stress signaling changes under chronic stress
Iron deficiency causes fatigue, brain fog, and hair loss long before anemia develops — ferritin below 50 ng/mL is symptomatic for many women
Serum B12 below 500 pg/mL may indicate functional deficiency even if within the conventional 'normal' range of 200–900 pg/mL