Condition Guide

You don't want to live longer. You want to live better, longer.

Nobody wants twenty extra years of decline. You want to be sharp at 80, strong at 70, energized at 60. The science is clear: the biggest threats to your quality of life — metabolic disease, cognitive decline, muscle loss, chronic inflammation — are largely preventable. But you have to start before they show up.

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These four things will take you down if you let them.

They're called the "four horsemen" — the diseases that steal the most years of quality life. The twist? They all share common root causes. And they all start decades before you feel a thing.

Metabolic Disease

Insulin resistance and type 2 diabetes are the foundation of most chronic disease. Blood sugar control is longevity's master lever.

Cardiovascular Disease

ApoB-driven atherosclerosis develops over decades. Early detection and lipid management save lives.

Neurodegenerative Disease

Alzheimer's and dementia start 20+ years before symptoms. Metabolic health, sleep, and exercise are protective.

Cancer

Chronic inflammation, metabolic dysfunction, and immune surveillance decline create the conditions for cancer growth.

These are the levers that actually move the needle.

Blood sugar balance and insulin sensitivity
Cardiovascular protection (ApoB, Lp(a))
Cognitive health and memory preservation
Muscle mass and functional strength
Sleep quality and circadian rhythm
Chronic inflammation reduction
VO2 max and cardiorespiratory fitness
Emotional resilience and purpose

Important Note

Longevity optimization works best with regular medical check-ups and appropriate screening. This guide complements — not replaces — working with a qualified healthcare provider who understands preventive medicine.

Why some people age faster than others.

Your biological age and your birthday age can be wildly different. These are the factors that speed up the clock — and every single one is modifiable if you know where to look.

Insulin Resistance

The #1 driver of accelerated aging and chronic disease risk

Chronic Inflammation

"Inflammaging" — low-grade inflammation that compounds decade after decade

Poor Sleep

Impairs glymphatic clearance, hormone production, and cellular repair

Muscle Loss

Sarcopenia begins in your 30s and accelerates — muscle is the organ of longevity

Mitochondrial Decline

Energy production drops, oxidative stress increases with age

Toxin Accumulation

Heavy metals, mold, and environmental chemicals impair cellular function

The playbook is simpler than you'd think.

You don't need exotic biohacks or expensive clinics. The most powerful longevity interventions are shockingly accessible — they just need to be done consistently, and most people aren't doing them right.

1

Exercise: The Most Powerful Longevity Drug

Exercise reduces all-cause mortality more than any other intervention. The key pillars:

Zone 2 cardio: 150–180 min/week for metabolic health
VO2 max training: High-intensity 1–2x/week
Resistance training: 3–4x/week for muscle and bone
Stability & mobility: Injury prevention, functional aging
2

Metabolic Optimization

Maintain excellent blood sugar control, prioritize protein for muscle synthesis (1g/lb target), eat whole foods rich in polyphenols and fiber, and practice time-restricted eating if appropriate. Consider a CGM to understand your personal glucose responses.

3

Sleep as Medicine

Sleep is when your brain detoxifies (glymphatic system), growth hormone peaks, and cellular repair occurs. Prioritize 7–9 hours of quality sleep with consistent timing. Poor sleep accelerates every aging pathway.

4

Cognitive & Emotional Health

Social connection, purpose, stress management, and continuous learning protect cognitive function. Loneliness is as dangerous as smoking for mortality risk. Invest in relationships, manage chronic stress, and maintain a sense of meaning and engagement.

5

Targeted Supplementation

Evidence-supported supplements for longevity (discuss with your practitioner):

Omega-3s: Anti-inflammatory, cardioprotective
Vitamin D3 + K2: Immune, bone, and cardiovascular
Creatine: Muscle, brain, and energy support
Magnesium: Sleep, metabolic, cardiovascular
Collagen peptides: Joint, skin, connective tissue
CoQ10: Mitochondrial function

The silent killers hiding in plain sight.

Sedentary lifestyle: Physical inactivity is the single greatest risk factor for premature death.
Chronic sleep deprivation: Consistently sleeping less than 7 hours accelerates every aging pathway.
Ultra-processed food diet: Drives inflammation, insulin resistance, and metabolic dysfunction.
Social isolation: Loneliness increases all-cause mortality risk by 26% — comparable to smoking.

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Frequently Asked Questions

Lifespan is simply how long you live, while healthspan refers to the years you live in good health — free from chronic disease and disability. Longevity medicine focuses on extending healthspan, not just adding years. The goal is to compress the period of decline so you stay vibrant and functional for as long as possible.

The top modifiable factors include metabolic health (blood sugar and insulin sensitivity), cardiovascular fitness, muscle mass and strength, sleep quality, stress management, and social connection. Research consistently shows that these lifestyle factors have a far greater impact on healthspan than genetics alone.

Muscle is your largest metabolic organ and a powerful predictor of longevity. Sarcopenia (age-related muscle loss) increases fall risk, metabolic dysfunction, and mortality. Resistance training and adequate protein intake are among the most evidence-backed interventions for extending both lifespan and healthspan.

Key longevity biomarkers include fasting insulin and glucose, HbA1c, apoB and lipid particles, hs-CRP (inflammation), homocysteine, vitamin D, DHEA-S, and hormone panels. A coronary artery calcium (CAC) score and regular metabolic testing help track your biological age versus chronological age.

Evidence-backed longevity supplements include omega-3 fatty acids, vitamin D, magnesium, CoQ10, creatine (for muscle and brain), collagen, and NAD+ precursors like NMN or NR. Resveratrol, quercetin, and spermidine are also being studied for their potential anti-aging effects. Quality and dosing matter enormously.

Sleep is when your body performs critical repair, detoxification, and memory consolidation. Chronic poor sleep accelerates biological aging, increases disease risk, impairs cognitive function, and disrupts hormones. Consistently getting 7-9 hours of quality sleep is one of the most powerful longevity interventions available.

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